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Effects of the serotonin 5-HT7 receptor antagonist SB-269970 on the inhibition of dopamine neuronal firing induced by amphetamine
- Source :
-
European Journal of Pharmacology . Sep2007, Vol. 570 Issue 1-3, p72-76. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: Using extracellular unitary recordings in anaesthetized rats, this study examined the implication of the serotonin 7 (5-HT7) receptors in the inhibitory effect of amphetamine on ventral tegmental area and substantia nigra pars compacta dopamine neuronal activity. The acute administration of the selective 5-HT7 receptor antagonist, SB-269970 (0.1, 0.5 and 1 mg/kg, i.p.), did not alter the firing activity of dopamine neurons. Interestingly, this antagonist prevented significantly the inhibition of dopamine neuronal firing activity induced by amphetamine (1 mg/kg, i.v.) in the ventral tegmental area, but not in the substantia nigra pars compacta. The present results suggest that 5-HT7 receptors modulate the dopamine firing activity in the ventral tegmental area, thus affecting preferentially the mesocorticolimbic pathway. [Copyright &y& Elsevier]
- Subjects :
- *PHARMACOLOGY
*MEDICAL sciences
*BIOLOGY
*LIFE sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 570
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 26249759
- Full Text :
- https://doi.org/10.1016/j.ejphar.2007.05.037