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Effects of the serotonin 5-HT7 receptor antagonist SB-269970 on the inhibition of dopamine neuronal firing induced by amphetamine

Authors :
Mnie-Filali, Ouissame
Dahan, Lionel
Zimmer, Luc
Haddjeri, Nasser
Source :
European Journal of Pharmacology. Sep2007, Vol. 570 Issue 1-3, p72-76. 5p.
Publication Year :
2007

Abstract

Abstract: Using extracellular unitary recordings in anaesthetized rats, this study examined the implication of the serotonin 7 (5-HT7) receptors in the inhibitory effect of amphetamine on ventral tegmental area and substantia nigra pars compacta dopamine neuronal activity. The acute administration of the selective 5-HT7 receptor antagonist, SB-269970 (0.1, 0.5 and 1 mg/kg, i.p.), did not alter the firing activity of dopamine neurons. Interestingly, this antagonist prevented significantly the inhibition of dopamine neuronal firing activity induced by amphetamine (1 mg/kg, i.v.) in the ventral tegmental area, but not in the substantia nigra pars compacta. The present results suggest that 5-HT7 receptors modulate the dopamine firing activity in the ventral tegmental area, thus affecting preferentially the mesocorticolimbic pathway. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00142999
Volume :
570
Issue :
1-3
Database :
Academic Search Index
Journal :
European Journal of Pharmacology
Publication Type :
Academic Journal
Accession number :
26249759
Full Text :
https://doi.org/10.1016/j.ejphar.2007.05.037