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Anxiolytic-like effects of oleamide in group-housed and socially isolated mice
- Source :
-
Progress in Neuro-Psychopharmacology & Biological Psychiatry . Aug2007, Vol. 31 Issue 6, p1189-1195. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract: Oleamide (cis-9,10-octadecenoamide) is an endogenous sleep-inducing lipid and prototypic member of a new class of biological signaling molecules identified in recent years. In the present study, the anxiolytic-like effect of oleamide was studied in several experimental models of anxiety in group-housed and socially isolated mice. As the results show, socially isolated mice exhibited an anxiogenic-like profile in the elevated plus-maze test, the light/dark test, and the hole-board test, which could be significantly reversed by oleamide (10 or 20 mg/kg, i.p.). Moreover, oleamide significantly reduced the anxiety levels in grouped-housed mice. In the isolation-induced aggressive test, oleamide markedly reduced the attacking duration and increased the attacking latency. It is concluded that oleamide has an anxiolytic-like effect in socially isolated or group-housed mice, which suggests that fatty acid amides might be involved in the regulation of anxiety-related behavior in mice. [Copyright &y& Elsevier]
- Subjects :
- *TRANQUILIZING drugs
*DIAZEPAM
*ANXIETY
*LABORATORY mice
Subjects
Details
- Language :
- English
- ISSN :
- 02785846
- Volume :
- 31
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Progress in Neuro-Psychopharmacology & Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 25937111
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2007.04.008