Detection of HIV Vaccine-Induced Cell-Mediated Immunity in HIV-Seronegative Clinical Trial Participants Using an Optimized and Validated Enzyme-Linked Immunospot Assay.

Authors :: Dubey, Sheri
Clair, James
Tong-Ming Fu
Liming Guan
Long, Romnie
Mogg, Robin
Anderson, Kiersten
Collins, Kelly B.
Gaun, Christine
Fernandez, V. Rose
Lan Zhu
Kierstead, Lisa
Thaler, Scott
Gupta, Swati B.
Straus, Walter
Mehrotra, Devan
Tobery, Timothy W.
Casimiro, Danilo R.
Shiver, John W.
Source :: JAIDS: Journal of Acquired Immune Deficiency Syndromes. 5/1/2007, Vol. 45 Issue 1, p20-27. 8p. 1 Chart, 5 Graphs.
Publication Year :: 2007
Abstract: The article discusses a study which examined HIV vaccine-induced cell-mediated immunity in HIV-seronegative subjects. HIV enzyme-linked immunospot assay (ELISPOT) was used to investigate the cell-mediated immunity. The study found a broad range of HIV-specific ELISPOT responses to peptide pools of overlapping 20mers, 15mers or 9mers in the subjects receiving DNA- or adenovirus vector-based HIV vaccines and in HIV-seropositive donors.

Subjects :: *CELLULAR immunity
*HIV-positive persons
*AIDS vaccines
*IMMUNOENZYME technique
*PEPTIDES

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