Searching the Candidate miRNA Related with Glucolipotoxicity-Induced Beta-Cell Dysfunction by miRNA Chip Analysis.

The article discusses a study on searching for functional microRNA (miRNA) in the beta-cells especially related with the diabetic status such as glucolipotoxicity. The study isolated 30 µg of total RNA and performed the miRNA chip array using an Ncode miRNA chip with primary rat islets. The study found that among 36 selected miRNA, 16 might be related with glucolipotoxicity-induced beta-cell dysfunction.