Spectrum of FGFR3 Mutations in Multiple Intraindividual Seborrheic Keratoses.

Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.Journal of Investigative Dermatology (2007) 127, 1883–1885; doi:10.1038/sj.jid.5700804; published online 29 March 2007 [ABSTRACT FROM AUTHOR]