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Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: Oxadiazolyl ketones
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2007, Vol. 17 Issue 15, p4167-4172. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure–activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic properties. In vivo pharmacodynamic efficacy and co-crystal structure of compound 18h with DPPIV is also described. [Copyright &y& Elsevier]
- Subjects :
- *KETONES
*CHEMICAL inhibitors
*PHARMACODYNAMICS
*PHARMACOKINETICS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 25618637
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.05.046