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Neuroprotective Effect of Bone MarrowâDerived Mononuclear Cells Promoting Functional Recovery from Spinal Cord Injury.
- Source :
-
Journal of Neurotrauma . Jun2007, Vol. 24 Issue 6, p1026-1036. 11p. - Publication Year :
- 2007
-
Abstract
- Neural cell transplantation, a new therapeutic strategy for replacing injured neural components and obtaining functional recovery, has shown beneficial effects in animal models. Use of this strategy in human patients, however, requires that a number of serious issues be addressed, including ethics, immunorejection, and the therapeutic time window within which the procedure will be effective. Bone marrowâderived mononuclear cells (BM-MNC) are attractive for transplantation because they can be used as an autograft, can be easily collected within a short time period, and do not have to be cultured. In a rat model of spinal cord injury (SCI), we transplanted BM-MNC at 1 h after SCI at Th 8â9 by injecting them into the cerebrospinal fluid (CSF), and investigated the effect of this on neurologic function. In the acute stage of injury, we found a neuroprotective antiapoptotic effect, with an elevated concentration of hepatocyte growth factor in CSF. At 1 week after transplantation, the BassoâBeattieâBresnahan locomotor score had increased significantly over its base-line value. In the chronic stage of injury, we observed suppressed cavity formation and functional improvement. We conclude that transplantation of BM-MNC after SCI has a remarkable neuroprotective effect in the acute stage of injury, suppressing cavity formation, and contributing to functional recovery. Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL transplantation
*MONONUCLEOSIS
*HEPATOCYTE growth factor
*AUTOGRAPHS
Subjects
Details
- Language :
- English
- ISSN :
- 08977151
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Neurotrauma
- Publication Type :
- Academic Journal
- Accession number :
- 25589510
- Full Text :
- https://doi.org/10.1089/neu.2007.132R