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Clusterin is associated with spontaneous breast cancer in TA2 mice
- Source :
-
FEBS Letters . Jul2007, Vol. 581 Issue 17, p3277-3282. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Two-dimensional electrophoresis and Matrix-assisted laser desorption ionization-time of flight-time of mass spectrometry were used to detect the differentially expressed proteins in serum of tientsin albinao 2 mice with spontaneous breast cancer, normal tientsin albinao 2 mice and tientsin albinao 1 mice. Only nuclear clusterin (n-CLU) was expressed in tientsin albinao 1. Immunohistochemistry and western blot validated that n-CLU was present in normal tientsin albinao 2 and tientsin albinao 1 mammary epithelium, and secretory clusterin expressed in the cytoplasm of normal tientsin albinao 2 mammary epithelium and spontaneous breast cancer. n-CLU may play an important role in tientsin albinao 2 spontaneous breast cancer initiation and development. [Copyright &y& Elsevier]
- Subjects :
- *GLYCOPROTEINS
*GLYCOCONJUGATES
*PROTEINS
*ACTIVIN
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 581
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 25569127
- Full Text :
- https://doi.org/10.1016/j.febslet.2007.06.021