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Alpha-Actinin-3 (ACTN3) R577X Polymorphism Influences Knee Extensor Peak Power Response to Strength Training in Older Men and Women.
- Source :
-
Journals of Gerontology Series A: Biological Sciences & Medical Sciences . Feb2007, Vol. 62 Issue 2, p206-212. 7p. 3 Charts, 2 Graphs. - Publication Year :
- 2007
-
Abstract
- Background. The alpha-actinin-3 (ACTN3) R577X polymorphism has been associated with muscle power performance in cross-sectional studies. Methods. We examined baseline knee extensor concentric peak power (PP) and PP change with ∼10 weeks of unilateral knee extensor strength training (ST) using air-powered resistance machines in 71 older men (65 [standard deviation = 81] years) and 86 older women (64 [standard deviation = 9] years). Results. At baseline in women, the XX genotype group had an absolute (same resistance) PP that was higher than the RR (p = .005) and RX genotype groups (p = .02). The women XX group also had a relative (70% of one-repetition maximum [1 -RM]) PP that was higher than that in the RR (p = .002) and RX groups (p = .008). No differences in baseline absolute or relative PP were observed between ACTN3 genotype groups in men. In men, absolute PP change with ST in the RR (n = 16) group approached a significantly higher value than in the XX group (n = 9; p = .07). In women, relative PP change with ST in the RR group (n = 16) was higher than in the XX group (n = 17; p = .02). Conclusions. The results indicate that the ACTN3 R577X polymorphism influences the response of quadriceps muscle power to ST in older adults. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 62
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25540148
- Full Text :
- https://doi.org/10.1093/gerona/62.2.206