Our approach to squamous intraepithelial lesions of the uterine cervix.

The article explains the criteria used in general surgical pathology practice and the potential risks and approaches to histological mimics of cervical neoplasia. It proposes the use of ancillary techniques such as immunohistochemistry for p16INK4a and MIB-1 (Ki-67), as well as human papillomavirus (HPV) in situ hybridization, in the grading of cervical intraepithelial neoplasia (CIN). Combined p16INK4a and Ki-67 is recommended in lesions morphologically suspicious for CIN.