Back to Search
Start Over
Rapid and Efficient Microwave-Assisted Synthesis of N-Carbamoyl-L-amino Acids.
- Source :
-
Synthetic Communications . 2007, Vol. 37 Issue 11, p1833-1844. 12p. 1 Diagram, 3 Charts. - Publication Year :
- 2007
-
Abstract
- A rapid and efficient method for the synthesis of N-carbamoyl-L-amino acids is reported. The procedure, involving the reaction between urea and α-amino acids sodium salts, was performed under microwave conditions using an unmodified domestic microwave oven. A careful study of the operative conditions indicated proline (1d) as the less reactive substrate and phenylglycine (1e) as the more reactive one among all the α-amino acids tested. Substitution of urea with potassium cyanate produced a low conversion into the corresponding N-carbamoyl derivative, and a possible explanation of this result is reported. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINO acids
*UREA
*ELECTRIC equipment
*MICROWAVE ovens
*NITROGEN excretion
*ACIDS
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 37
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 25359973
- Full Text :
- https://doi.org/10.1080/00397910701317068