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Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2007, Vol. 17 Issue 12, p3412-3416. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: A series of substituted bis[(para-methoxy)benzyl] (bisPMB) esters of 1-naphthalenemethylphosphonate (NMPA) were synthesized and evaluated as phosphonate prodrugs. BisPMB NMPA esters (4b and 4c) with significantly improved aqueous stability were identified that also resulted in increased intracellular levels of NMPA following prodrug incubation with primary rat hepatocytes. [Copyright &y& Elsevier]
- Subjects :
- *ORGANIC compounds
*PRODRUGS
*ESTERS
*LIVER cells
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 25342254
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.03.089