Alzheimer Research Forum Discussion: Gain or Loss of Function – Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

The article presents comments on Alzheimer's disease (AD) research. Peter Davies of Albert Einstein College of Medicine comments on a paper by Bart De Strooper and colleagues which explored the effects of presenilin (PS) mutations on the processing of amyloid precursor protein (APP). Hui Zheng of Baylor College of Medicine cited two papers which employed the use of cell cultures and human samples to study the pathogenic mechanisms of PS familial AD (FAD) mutations.