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Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
- Source :
-
Nature Genetics . Jun2007, Vol. 39 Issue 6, p733-740. 8p. 1 Diagram, 2 Charts, 4 Graphs. - Publication Year :
- 2007
-
Abstract
- Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns and inhibitory capacity upon binding to their ligands, HLA-B Bw4 molecules, present on target cells. Using a sample size of over 1,500 human immunodeficiency virus (HIV)+ individuals, we show that various distinct allelic combinations of the KIR3DL1 and HLA-B loci significantly and strongly influence both AIDS progression and plasma HIV RNA abundance in a consistent manner. These genetic data correlate very well with previously defined functional differences that distinguish KIR3DL1 allotypes. The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*HTLV
*HIV infections
*KILLER cells
*AIDS
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25210268
- Full Text :
- https://doi.org/10.1038/ng2035