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The excess in 2-5 mm follicles seen at ovarian ultrasonography is tightly associated to the follicular arrest of the polycystic ovary syndrome.
- Source :
-
Human Reproduction . Jun2007, Vol. 22 Issue 6, p1562-1562. 1p. - Publication Year :
- 2007
-
Abstract
- BACKGROUND We previously hypothesized that the excess of 2â5 mm follicles seen at ovarian ultrasonography might be involved in the follicular arrest (FA) of polycystic ovary syndrome (PCOS), independently from the main putative contributors of FA, namely hyperandrogenism and hyperinsulinism. METHODS A multivariate statistical analysis was applied retrospectively to clinical, biological and ultrasound data that were consecutively collected during 5 years in 457 patients with polycystic ovaries and in 188 age-matched non-hyperandrogenic and regularly cycling controls without PCO at ultrasound. RESULTS Stepwise discriminant analysis indicated that in PCOS the 2â5 mm follicle number (FN) gave the strongest correlation to severity of the FA, followed by age and then by fasting insulin level. The other variables [waist circumference (WC), 6â9 mm FN, serum testosterone, FSH, LH and ovarian area] were rejected by the analysis. Multiple linear regression indicated a significant and independent negative relationship between the 2â5 and 6â9 mm FN in the PCOS (r = â 0.186, P r = â 0.281, P r = â 0.108, P CONCLUSIONS The size of the 2â5 mm follicle pool is an independent and important contributor to the FA of PCOS. This result could be explained by an exaggerated physiological inhibitory effect from this pool on the terminal follicle growth. The metabolic derangement of PCOS that also contributes to the FA would act through a different mechanism. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ULTRASONIC imaging
*POLYCYSTIC ovary syndrome
*HYPERANDROGENISM
*INSULIN
Subjects
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 22
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 25208820
- Full Text :
- https://doi.org/10.1093/humrep/dem060