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Prognostic significance of the admission plasma B-type natriuretic peptide measurement in patients with first ST-elevation myocardial infarction in comparison with C-reactive protein and TIMI risk score
- Source :
-
Clinica Chimica Acta . Jul2007, Vol. 382 Issue 1/2, p106-111. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Background: In ST-elevation myocardial infarction (STEMI) B-type natriuretic peptide (BNP) holds promise for risk stratification. Aim of this study was to assess prognostic value of plasma BNP measurement and to compare with other powerful prognostic markers — TIMI Risk Score (TRS) and C-reactive protein (CRP) in patients with first STEMI treated with primary PCI (pPCI). Methods: 86 patients, admitted within initial 12 h of the first STEMI. Admission plasma levels of BNP were measured by MEIA method. Serum levels of CRP were measured using immunoturbidimetric assays. Composite end point (CEP) was assessed after 7 months. Results: Median plasma BNP value was higher in patients with CEP, compared with those without CEP (p <0.001). Patients with plasma BNP >99.2 pg/mL were at significantly higher risk for CEP (the highest sensitivity and specificity). CRP level >10.6 mg/dL was also associated with poor outcome. TRS has not influenced the occurrence of CEP. In the analysis of logistic regression the BNP value >99.2 pg/mL was the strongest predictor of CEP. ROC analysis identified BNP measurement as significant to estimate adverse outcome 0.950 in the prediction of CEP (95% Confidence interval=0.878–0.985). Conclusion: Admission plasma BNP concentrations provide incremental prognostic information in patients with first STEMI treated with pPCI. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 382
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 25187193
- Full Text :
- https://doi.org/10.1016/j.cca.2007.04.002