Microwave-promoted automated synthesis of a coumarin library.

Authors :: Katkevičs, M.
Kontijevskis, A.
Mutule, I.
Sūna, E.
Source :: Chemistry of Heterocyclic Compounds. Feb2007, Vol. 43 Issue 2, p151-159. 9p. 1 Diagram, 1 Chart, 1 Graph.
Publication Year :: 2007
Abstract: A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible. [ABSTRACT FROM AUTHOR]