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Calcium homeostasis and modulation of synaptic plasticity in the aged brain.
- Source :
-
Aging Cell . Jun2007, Vol. 6 Issue 3, p319-325. 7p. 4 Diagrams. - Publication Year :
- 2007
-
Abstract
- The level of intracellular Ca2+ plays a central role in normal and pathological signaling within and between neurons. These processes involve a cascade of events for locally raising and lowering cytosolic Ca2+. As the mechanisms for age-related alteration in Ca2+ dysregulation have been illuminated, hypotheses concerning Ca2+ homeostasis and brain aging have been modified. The idea that senescence is due to pervasive cell loss associated with elevated resting Ca2+ has been replaced by concepts concerning changes in local Ca2+ levels associated with neural activity. This article reviews evidence for a shift in the sources of intracellular Ca2+ characterized by a diminished role for N-methyl-D-aspartate receptors and an increased role for intracellular stores and voltage-dependent Ca2+ channels. Physiological and biological models are outlined, which relate a shift in Ca2+ regulation with changes in cell excitability and synaptic plasticity, resulting in a functional lesion of the hippocampus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CALCIUM
*BRAIN
*AGING
*NERVOUS system
*NEUROPLASTICITY
Subjects
Details
- Language :
- English
- ISSN :
- 14749718
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Aging Cell
- Publication Type :
- Academic Journal
- Accession number :
- 25088751
- Full Text :
- https://doi.org/10.1111/j.1474-9726.2007.00283.x