Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.

Authors :: Lahortiga, Idoya
De Keersmaecker, Kim
Van Vlierberghe, Pieter
Graux, Carlos
Cauwelier, Barbara
Lambert, Frederic
Mentens, Nicole
Beverloo, H. Berna
Pieters, Rob
Speleman, Frank
Odero, Maria D.
Bauters, Marijke
Froyen, Guy
Marynen, Peter
Vandenberghe, Peter
Wlodarska, Iwona
Meijerink, Jules P. P.
Cools, Jan
Source :: Nature Genetics. May2007, Vol. 39 Issue 5, p593-595. 3p. 1 Black and White Photograph, 3 Graphs.
Publication Year :: 2007
Abstract: We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL. [ABSTRACT FROM AUTHOR]