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Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy.
- Source :
-
Cellular & Molecular Life Sciences . May2007, Vol. 64 Issue 9, p1158-1168. 11p. 2 Charts, 10 Graphs. - Publication Year :
- 2007
-
Abstract
- In this study we have assessed the effect of testosterone (T), dihydrotestosterone (DHT) and 5αandrostan-3α, 17β-diol (3α-diol) therapies on diabetic neuropathy. Diabetes was induced in adult male rats by the injection of streptozotocin and resulted in decreased T and increased 3α-diol levels in plasma and in decreased levels of pregnenolone and DHT in the sciatic nerve. Moreover, a reduced expression of the enzyme converting Tinto DHT ( i.e., the 5α-reductase) also occurs at the level of sciatic nerve, suggesting that the decrease of DHT levels could be due to an impairment of this enzyme. Chronic treatment for 1 month with DHT or 3α-diol increased tail nerve conduction velocity and partially counteracted the increase of thermal threshold induced by diabetes. Treatment with DHT increased tibial Na+,K+-ATPase activity and the expression of myelin protein P0 in the sciatic nerve.DHT, 3α-diol and T reversed the reduction of intra-epidermal nerve fiber density induced by diabetes. These observations indicate that T metabolites can reverse behavioral, neurophysiological, morphological and biochemical alterations induced by peripheral diabetic neuropathy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TESTOSTERONE
*ANDROGENS
*STANOLONE
*PERFORMANCE-enhancing drugs
*ANDROSTANE
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X
- Volume :
- 64
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Cellular & Molecular Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24940334
- Full Text :
- https://doi.org/10.1007/s00018-007-7002-5