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Role of COL4A1 in Small-Vessel Disease and Hemorrhagic Stroke.
- Source :
-
New England Journal of Medicine . 4/6/2006, Vol. 354 Issue 14, p1489-1496. 1p. - Publication Year :
- 2006
-
Abstract
- Small-vessel diseases of the brain underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. In this report, we show that a mutation in the mouse Col4a1 gene, encoding procollagen type IV α1, predisposes both newborn and adult mice to intracerebral hemorrhage. Surgical delivery of mutant mice alleviated birth-associated trauma and hemorrhage. We identified a COL4A1 mutation in a human family with small-vessel disease. We concluded that mutation of COL4A1 may cause a spectrum of cerebrovascular phenotypes and that persons with COL4A1 mutations may be predisposed to hemorrhage, especially after environmental stress. N Engl J Med 2006;354:1489-96. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00284793
- Volume :
- 354
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- New England Journal of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24928793
- Full Text :
- https://doi.org/10.1056/NEJMoa053727