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Efficient vagina-to-lower respiratory tract immune trafficking in a murine model of influenza A virus infection
- Source :
-
Virology . May2007, Vol. 361 Issue 2, p274-282. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: Effective vaccination strategies for infectious diseases take into account the induction, long-term maintenance and recall of memory T-cell populations. To understand the immunological cross-talk within the mucosal compartments, we compared intranasal to vaginal immunization and demonstrated that vaginal infection of BALB/c mice with influenza A virus provides protective mucosal immunity against both homosubtypic and heterosubtypic virus challenge in the respiratory tract. We found that, prior to the viral challenge, in vaginally primed mice, antigen-specific CD8+ T cells were not detected in the lung airways and levels of serum antibodies were lower than those observed in intranasally immunized mice. However, following pulmonary challenge, NP147-specific CD8+ T cells were recruited and amplified in vaginally primed mice to the same extent as those in intranasally primed mice. Thus, the long-term memory immune response elicited by vaginal immunization with influenza virus is efficiently recalled and offers reasonable protection against infection in the respiratory tract. [Copyright &y& Elsevier]
- Subjects :
- *INFLUENZA viruses
*VIRUS diseases
*IMMUNIZATION
*COMMUNICABLE diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Volume :
- 361
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 24782191
- Full Text :
- https://doi.org/10.1016/j.virol.2006.12.001