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Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress
- Source :
-
Vascular Pharmacology . Jun2007, Vol. 46 Issue 6, p427-438. 12p. - Publication Year :
- 2007
-
Abstract
- Abstract: Aim: We have previously proved that oxidized low-density lipoprotein (oxLDL), a proatherogenic lipoprotein, plays a pivotal role in the development of atherosclerotic calcification (AC). The present study was performed to investigate whether tanshinone II A (TS II A), an anti-oxidant which has been shown to inhibit in vitro oxidation of LDL, has the effects to inhibit AC in rat model and by which, if any, mechanisms. Methods: Rat AC model was induced by excessive vitamin D2 (VD) and high cholesterol diet (HCD), which was proven to be successful histopathologically and biochemically. Results: Administration of AC rats with TS II A (35, 70 mg/kg) dose-dependently attenuated the AC pathological changes, meanwhile reduced the vessel contents of lipid and calcium. However, TS II A had no effects on serum levels of lipids, calcium and 25-OH VD. Further studies revealed that TS II A decreased serum concentration of oxLDL, reduced the superoxide anion production and malondialdehyde (MDA) in vessel. In addition, TS II A increased vessel Cu/Zn SOD activity, upregulated vessel mRNA and protein expression of Cu/Zn SOD. Conclusion: The results suggested that TS II A significantly attenuated the AC in rat model, which might be attributed to its inhibition of oxLDL production independent of the serum levels of lipids, calcium and 25-OH VD, and that increasing of Cu/Zn SOD activity as well as mRNA and protein expression by TS II A might protect LDL against oxidation induced by superoxide anion in vessel. [Copyright &y& Elsevier]
- Subjects :
- *ANTIOXIDANTS
*LOW density lipoproteins
*LIPOPROTEINS
*RATS
*CALCIUM
*OXIDATION
Subjects
Details
- Language :
- English
- ISSN :
- 15371891
- Volume :
- 46
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Vascular Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 24710475
- Full Text :
- https://doi.org/10.1016/j.vph.2007.01.001