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Synthesis and Evaluation of a Pseudocyclic Tristhiourea-Based Anion Host.
- Source :
-
Journal of Organic Chemistry . 3/30/2007, Vol. 72 Issue 7, p2289-2296. 8p. 5 Diagrams, 2 Charts, 12 Graphs. - Publication Year :
- 2007
-
Abstract
- A novel methodology for the evaluation of receptor arrangement in structurally flexible anion chemosensors was developed and applied to map the binding site of a new pseudocyclic tristhiourea chemosensor (6). The syntheses of 6 and related macrocyclic chemosensor 10 (a model of the folded monomeric structure of 6) are reported. Both chemosensors were evaluated by titration with a variety of structurally different anions in CH3CI and DMSO, showing a common preference for F-, CH3CO2-, and H2PO4-. However, within this group of anions, the binding patterns of the chemosensors differed, indicating dissimilarity in the arrangement of the binding sites of 6 and 10. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THIOUREA
*ANIONS
*BINDING sites
*MACROCYCLIC compounds
*CHEMICAL detectors
*MONOMERS
Subjects
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 72
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24689796
- Full Text :
- https://doi.org/10.1021/jo061774m