Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study.

The article presents the results of a literature review conducted by the authors that examined the putative genetic risk factors for acute coronary syndromes. The authors genotyped white patients with acute coronary syndromes and controls for variants in genes in an attempt to duplicate associations of the genetic variants with risk factors for acute coronary syndromes that had previously been reported. The authors found that none of the genetic variants tested were risk factors for acute coronary syndromes. The authors state that the previously reported studies linking the genetic variations to acute coronary syndromes need to be replicated before their findings are put into clinical practice.