Back to Search
Start Over
Quantitative demonstration of intrathecal synthesis of high affinity immunoglobulin G in herpes simplex encephalitis using affinity-mediated immunoblotting
- Source :
-
Journal of Neuroimmunology . Apr2007, Vol. 185 Issue 1/2, p130-135. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Three paired serial samples of CSF and serum (from days 8, 13 and 22) were taken from a patient referred to the National Hospital for Neurology and Neurosurgery with what was duly confirmed as having herpes simplex encephalitis using PCR. The samples were investigated using affinity-mediated immunoblotting followed by incubation with sodium thiocyanate. Digitisation of the blots enabled further analysis. We showed that the clones of antigen-specific IgG, which were produced intrathecally, were of higher relative affinity than polyclonal antigen-specific IgG. [Copyright &y& Elsevier]
- Subjects :
- *SKIN infections
*BRAIN diseases
*BLOOD plasma
*NEUROLOGICAL disorders
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 185
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 24553923
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2007.01.002