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Characterisation of cyclin D1 down-regulation in coronavirus infected cells
- Source :
-
FEBS Letters . Apr2007, Vol. 581 Issue 7, p1275-1286. 12p. - Publication Year :
- 2007
-
Abstract
- Abstract: The positive strand RNA coronavirus, infectious bronchitis virus (IBV), induces a G2/M phase arrest and reduction in the G1 and G1/S phase transition regulator cyclin D1. Quantitative real-time RT-PCR and Western blot analysis demonstrated that cyclin D1 was reduced post-transcriptionally within infected cells independently of the cell-cycle stage at the time of infection. Confocal microscopy revealed that cyclin D1 decreased in IBV-infected cells as infection progressed and inhibition studies indicated that a population of cyclin D1 could be targeted for degradation by a virus mediated pathway. In contrast to the SARS-coronavirus, IBV nucleocapsid protein did not interact with cyclin D1. [Copyright &y& Elsevier]
- Subjects :
- *VIRUSES
*MICROSCOPY
*NUCLEIC acids
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 581
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 24461655
- Full Text :
- https://doi.org/10.1016/j.febslet.2007.02.039