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A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
- Source :
-
Leukemia (08876924) . Apr2007, Vol. 21 Issue 4, p647-650. 4p. 2 Graphs. - Publication Year :
- 2007
-
Abstract
- Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARbeta and RARgamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARalpha locus in leukemia patients must occur--rather than through functional differences among the various RAR isoforms-as the consequence of the nuclear architecture of the different RAR loci. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RETINOIDS
*RECEPTOR antibodies
*ONCOGENIC DNA viruses
*LEUKEMIA
*CHROMOSOMAL translocation
*GENETIC vectors
*GENE transfection
*PATIENTS
*ANIMAL experimentation
*CELL lines
*CELL receptors
*CHROMOSOME abnormalities
*COMPARATIVE studies
*GENETIC techniques
*RESEARCH methodology
*MEDICAL cooperation
*MICE
*PROTEINS
*RESEARCH
*RNA
*EVALUATION research
*ACUTE promyelocytic leukemia
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Leukemia (08876924)
- Publication Type :
- Academic Journal
- Accession number :
- 24458757
- Full Text :
- https://doi.org/10.1038/sj.leu.2404572