Preparation of superparamagnetic nanocomposite particles for hyperthermia therapy application

Abstract: Superparamagnetic nanocomposite particles prepared by the ultrasonic spray pyrolysis were used in localized hyperthermia therapy, one of the many therapy options for cancer treatment. The primary particle size of the Fe2O3/MgO nanocomposite particles prepared at 800°C was approximately 10nm. The particles show superparamagnetic properties with a blocking temperature of −148°C. Heat generated by an alternating magnetic field of 60Oe increases the tissue temperature to 42.5°C after 125s. [Copyright &y& Elsevier]