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Cognitive and Serotonergic Vulnerability to Depression: Convergent Findings.
- Source :
-
Journal of Abnormal Psychology . Feb2007, Vol. 116 Issue 1, p86-94. 9p. 3 Charts. - Publication Year :
- 2007
-
Abstract
- Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed patients participated in 2 ATD sessions in a double-blind crossover design. CR, assessed prior to the ATD sessions, predicted depressive response to high-dose ATD. CR also diminished the effects of 2 known predictors of ATD response: gender and residual symptoms. Neuroticism and behavioral inhibition were unrelated to ATD response. CR is associated with an increased sensitivity to reductions of serotonin concentrations. These findings present a small step toward unifying cognitive and neurobiological theories of depression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0021843X
- Volume :
- 116
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Abnormal Psychology
- Publication Type :
- Academic Journal
- Accession number :
- 24168459
- Full Text :
- https://doi.org/10.1037/0021-843X.116.1.86