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Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure
- Source :
-
Autonomic Neuroscience: Basic & Clinical . Mar2007, Vol. 132 Issue 1/2, p76-80. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: Introduction: Human heart beats in an extremely inhomogeneous and non-stationary manner. Recent study has demonstrated that it belongs to a class of signals called multifractal. Loss of multifractality was also uncovered in patients with congestive heart failure. We investigated whether carvedilol could restore the multifractal properties in a group of patients with advanced congestive heart failure. Methods and results: A Holter ECG recording was obtained before and 1 and 3 months after titrated addition of carvedilol therapy in 10 patients with advanced congestive heart failure. Multifractal spectrum, detrended fluctuation analysis (DFA) as well as the traditional time- and frequency-domain heart rate variability (HRV) parameters were compared before and after carvedilol therapy together with those in age and sex-matched normal control. The results showed that the multifractal spectrum τ(q) vs. q of N–N interval time series returned toward normal during carvedilol treatment. All the tranditional HRV parameters and the short-term DFA improved significantly after 3 months of carvedilol therapy. Conclusion: We concluded that the deteriorated multifractal properties could be reversed by carvedilol treatment in patients with advanced congestive heart failure. [Copyright &y& Elsevier]
- Subjects :
- *HEART beat
*HEART failure
*ELECTROCARDIOGRAPHY
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 15660702
- Volume :
- 132
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Autonomic Neuroscience: Basic & Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 24142046
- Full Text :
- https://doi.org/10.1016/j.autneu.2006.10.008