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Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence
- Source :
-
Trends in Microbiology . Feb2007, Vol. 15 Issue 2, p51-53. 3p. - Publication Year :
- 2007
-
Abstract
- Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV compared with related coronaviruses, which cause lesser respiratory illnesses, has recently focused on the unique nsp1 protein of SARS-CoV and suggests evolution of a possible new virulence mechanism in coronaviruses. The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV replication or block immune responses. [Copyright &y& Elsevier]
- Subjects :
- *SARS disease
*CORONAVIRUSES
*PROTEINS
*VIRAL replication
*IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 0966842X
- Volume :
- 15
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Trends in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23947261
- Full Text :
- https://doi.org/10.1016/j.tim.2006.12.005