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A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
- Source :
-
Oncogene . 2/8/2007, Vol. 26 Issue 6, p851-858. 8p. 1 Chart, 5 Graphs. - Publication Year :
- 2007
-
Abstract
- Tumor markers can facilitate understanding molecular cell biology of neoplasia and provide potential targets for the diagnosis and insight for intervention. We here identify a novel murine gene, hepcarcin (hcn), encoding a 7-kb mRNA-like transcript. The gene appears to be the murine ortholog of the human alpha gene, that is, MALAT-1. The gene and homologs lack credible open reading frames, consistent with a highly conserved large noncoding RNA (ncRNA). In all nodules of procarcinogen-induced murine hepatocellular carcinomas (HCCs) and human HCCs, expression was markedly elevated compared to the uninvolved liver. Quantitative analyses indicated a 6–7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest. This ncRNA was overexpressed in all five non-hepatic human carcinomas analysed, consistent with a potential marker for neoplastic cells and potential participant in the molecular cell biology of neoplasia.Oncogene (2007) 26, 851–858. doi:10.1038/sj.onc.1209846; published online 31 July 2006 [ABSTRACT FROM AUTHOR]
- Subjects :
- *TUMOR markers
*BIOMARKERS
*LIVER cancer
*CANCER
*CANCER genetics
*MICE
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 09509232
- Volume :
- 26
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 23937780
- Full Text :
- https://doi.org/10.1038/sj.onc.1209846