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Synthesis of a Library of 2-Alkyl-3-alkyloxy-2H-indazole-6-carboxamides.
- Source :
-
Journal of Combinatorial Chemistry . Jan2007, Vol. 9 Issue 1, p171-177. 7p. - Publication Year :
- 2007
-
Abstract
- A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10 mg scale. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMIDES
*ALCOHOL
*ACRYLAMIDE
*RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 15204766
- Volume :
- 9
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Combinatorial Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23925889
- Full Text :
- https://doi.org/10.1021/cc060109o