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Crystal structure of apo-calmodulin bound to the first two lQ motifs of myosin V reveals essential recognition features.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 12/19/2006, Vol. 103 Issue 51, p19326-19331. 6p. 5 Diagrams. - Publication Year :
- 2006
-
Abstract
- A 2.5-Å resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the first part of the IQ motif (lQxxxR). whereas the N-terminal lobe adopts a closed conformation that interacts more weakly with the second part of the motif (GxxxR). Variable residues in the lQ motif play a critical role in determining the precise structure of the bound CaM, such that even the consensus residues of different motifs show unique interactions with CaM. This complex serves as a model for the lever arm region of many classes of unconventional myosins, as well as other IQ motif-containing proteins such as neuromodulin and IQGAPs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CRYSTALS
*CALMODULIN
*CALCIUM
*MYOSIN
*MUSCLE proteins
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 103
- Issue :
- 51
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 23873303
- Full Text :
- https://doi.org/10.1073/pnas.0609436103