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Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 1/9/2007, Vol. 104 Issue 2, p594-599. 6p. 5 Graphs. - Publication Year :
- 2007
-
Abstract
- Regulatory T cells play an essential role in preventing fetal rejection by the maternal immune system. Here we show that, based on the expression of CCR5, regulatory T cells can be divided into a highly suppressive CCR5+ and a far less suppressive CCRS- sub-population, suggesting that the former represent the effector arm of regulatory T cells. Although regulatory T ceils from CCR5-/- gene deletion mutants still suppress, they are less effective mediators of maternal-fetal tolerance. The accumulation of CCR5+ regulatory T cells at this site appears to be enhanced by alloantigen. This finding is in stark contrast to the systemic expansion of regulatory T cells during pregnancy, which appears to be alloantigen-independent. The fact that CCR5+ regulatory T cells preferentially accumulate in the gravid uterus and that expression of CCR5 on regulatory T cells can be induced by activation lead us to propose that CCR5 is responsible for the accumulation of those regulatory T cells that have been activated by paternal antigens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*LYMPHOCYTES
*IMMUNE system
*PREGNANT women
*LEUCOCYTES
*PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 104
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 23817182
- Full Text :
- https://doi.org/10.1073/pnas.0604268104