Back to Search
Start Over
Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2007, Vol. 17 Issue 3, p750-755. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: A novel class of adamantane ethers 11β-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure–activity relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1 are discussed. [Copyright &y& Elsevier]
- Subjects :
- *ETHERS
*ADAMANTANE
*BIOSYNTHESIS
*HYDROGENASE
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 23740368
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.10.074