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Netrins Promote Developmental and Therapeutic Angiogenesis.

Authors :
Wilson, Brent D.
Li, Masaaki
Kye Won Park
Suli, Arminda
Sorensen, Use K.
Larrieu-Lahargue, Fréderic
Urness, Lisa D.
Wonhee Suh
Asai, Jun
Kock, Gerhardus A. H.
Thorne, Tina
Silver, Marcy
Thomas, Kirk R.
Chin-Bin Chien
Losordo, Douglas W.
Li, Dean Y.
Source :
Science. 8/4/2006, Vol. 313 Issue 5787, p640-644. 5p.
Publication Year :
2006

Abstract

Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrinla messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00368075
Volume :
313
Issue :
5787
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
23600894
Full Text :
https://doi.org/10.1126/science.1124704