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Effect of dehydroepiandrosterone (DHEA) treatment on oxidative energy metabolism in rat liver and brain mitochondria. A dose–response study
- Source :
-
Clinical Biochemistry . Jan2007, Vol. 40 Issue 1/2, p57-65. 9p. - Publication Year :
- 2007
-
Abstract
- Abstract: Objectives: : Effects of treatment with dehydroepiandrosterone (DHEA) on oxidative energy metabolism in rat liver and brain mitochondria were examined. Design and methods: : Young adult rats were administered DHEA (0.1, 0.2, 1.0 or 2.0 mg/kg body weight) by subcutaneous route for 7 consecutive days. Results: : DHEA treatment resulted in general, in stimulation of state 3 respiration rates without having any uncoupling effect on ADP/O ratios. The stimulation of state 3 respiration rate for a given substrate was dose dependent in a tissue-specific manner. Parallel increases in the contents of cytochromes aa3 and b were also noted. DHEA treatment stimulated the glutamate dehydrogenase (GDH) and succinate DCIP reductase (SDR) activities. Under the treatment conditions, mitochondrial ATPase activity was also stimulated. Conclusions: : Treatment with DHEA significantly stimulated oxidative energy metabolism in liver and brain mitochondria. [Copyright &y& Elsevier]
- Subjects :
- *DEHYDROEPIANDROSTERONE
*ENERGY metabolism
*MITOCHONDRIA
*LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 00099120
- Volume :
- 40
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Clinical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23569572
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2006.08.014