Back to Search
Start Over
IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
- Source :
-
Microbes & Infection . Nov2006, Vol. 8 Issue 14/15, p2880-2889. 10p. - Publication Year :
- 2006
-
Abstract
- Abstract: The role of IL-13 in respiratory syncytial virus (RSV) immunopathogenesis is incompletely described. To assess the effect of IL-13 on primary RSV infection, transgenic mice which either overexpress IL-13 in the lung (IL-13 OE) or non-transgenic littermates (IL-13 NT) were challenged intranasally with RSV. IL-13 OE mice had significantly decreased peak viral titers four days after infection compared to non-transgenic littermates. In addition, IL-13 OE mice had significantly lower RSV-induced weight loss and reduced lung IFN-γ protein expression compared with IL-13 NT mice. In contrast, primary RSV challenge of IL-13 deficient mice resulted in a small, but statistically significant increase in viral titers on day four after infection, no difference in RSV-induced weight loss compared to wild type mice, and augmented IFN-γ production on day 6 after infection. In STAT1-deficient (STAT1 KO) mice, where primary RSV challenge produced high levels of IL-13 production in the lungs, treatment with an IL-13 neutralizing protein resulted in greater peak viral titers both four and six days after RSV and greater RSV-induced weight loss compared to mice treated with a control protein. These results suggest that IL-13 modulates illness from RSV-infection. [Copyright &y& Elsevier]
- Subjects :
- *THERAPEUTIC use of cytokines
*CELLULAR immunity
*RESPIRATORY syncytial virus
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 12864579
- Volume :
- 8
- Issue :
- 14/15
- Database :
- Academic Search Index
- Journal :
- Microbes & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 23449587
- Full Text :
- https://doi.org/10.1016/j.micinf.2006.09.007