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Evidence that the β-acids fraction of hops reduces central GABAergic neurotransmission
- Source :
-
Journal of Ethnopharmacology . Jan2007, Vol. 109 Issue 1, p87-92. 6p. - Publication Year :
- 2007
-
Abstract
- Abstract: Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop β-acids on central nervous system function. Oral administration of β-acids (5–10mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures. When dosed at 10mg/kg, β-acids increased, in the elevated plus maze, open arm entries reducing in parallel those in closed arms. In the forced swimming test, we observed a reduction in the immobility time that could suggest an antidepressant-like activity. Electrophysiological studies performed on cerebellar granule cells in culture showed that the β-acids fraction decreased GABA-evoked current in a dose-dependent way. The effect was not inhibited by the benzodiazepine antagonist Ro 15-1788. Benzodiazepine receptors involvement was also excluded by [3H]-Ro 15-1788 binding assay. In conclusion, the behavioral effects of β-acids fraction could be explained by a reduction in the GABAergic activity although we cannot rule out the involvement of other neurotransmitter systems. [Copyright &y& Elsevier]
- Subjects :
- *HOPS
*HERBAL medicine
*NEURAL transmission
*CENTRAL nervous system
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 109
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23281070
- Full Text :
- https://doi.org/10.1016/j.jep.2006.07.008