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Preparation and application of chiral spiro nitrogen-containing ligands for cobalt-catalyzed asymmetric Michael addition
- Source :
-
Tetrahedron: Asymmetry . Oct2006, Vol. 17 Issue 19, p2761-2767. 7p. - Publication Year :
- 2006
-
Abstract
- Abstract: Two novel chiral spiro nitrogen-containing ligands, 7,7′-bis(2-pyridinecarboxamido)-1,1′-spirobiindane (abbreviated as SIPAD) and 7,7′-bis(2-quinolinecarboxamido)-1,1′-spirobiindane (abbreviated as SIQAD), were conveniently prepared from 1,1′-spirobiindane-7,7′-dicarboxylic acid in high yields (85% and 84%, respectively) in two steps. The cobalt complexes prepared in situ from Co(OAc)2 and the ligands have been proven to be efficient catalysts for the asymmetric Michael addition reaction of malonates to chalcone derivatives. The alkylation products were obtained in high yields with moderate enantiomeric excesses under mild reaction conditions. [Copyright &y& Elsevier]
- Subjects :
- *LIGANDS (Chemistry)
*BIOCHEMISTRY
*ORGANIC compounds
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 17
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 23207779
- Full Text :
- https://doi.org/10.1016/j.tetasy.2006.10.006