Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system

Authors :: Evdokimov, Nikolai M.
Kireev, Artem S.
Yakovenko, Andrey A.
Antipin, Mikhail Yu.
Magedov, Igor V.
Kornienko, Alexander
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2006, Vol. 47 Issue 52, p9309-9312. 4p.
Publication Year :: 2006
Abstract: Abstract: Benzopyrano[2,3-b]pyridine is an important privileged medicinal scaffold. A three-component reaction of salicylaldehydes, thiols and 2equiv of malononitrile that leads to the formation of a series of compounds incorporating 2,4-diamino-3-cyano-5-sulfanylbenzopyrano[2,3-b]pyridine framework is described. A proposed mechanism with the supporting experimental data is presented. [Copyright &y& Elsevier]

Subjects :: *PYRIDINE
*THIOLS
*RING formation (Chemistry)
*CHEMICAL reactions

Language :: English
ISSN :: 00404039
Volume :: 47
Issue :: 52
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 23206494
Full Text :: https://doi.org/10.1016/j.tetlet.2006.10.110

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