Alzheimer's APP mangles mitochondria.

The article presents a study by Anandatheerthavarada and others on the impairment of mitochondrial function in Alzheimer disease. The article discovers the presence of nonglycosylated full-length and C-terminally-truncated amyloid precursor protein (APP) associated with mitochondria in brain samples from Alzheimer disease patients. The article discusses the presence of higher levels of mitochondrial APP in more affected brain areas. The article concludes with the complicated effects of APP.