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c-FlipL is expressed in undifferentiated mouse male germ cells
- Source :
-
FEBS Letters . Nov2006, Vol. 580 Issue 26, p6109-6114. 6p. - Publication Year :
- 2006
-
Abstract
- Abstract: Apoptosis represents a fundamental process during fetal/post-natal testis development. Therefore pro- and anti-apoptotic proteins are essential to regulate testis physiology. c-FlipL is a known inhibitor of caspase 8/10 activity; in this study its perinatal expression in mouse male germ cells was investigated. In testis sections and seminiferous tubule whole mount c-FlipL was found to be expressed in undifferentiated spermatogonia and to co-localize with germ stem cells markers. In vivo investigations in the vitamin-A deficient mouse, lacking differentiated germ cells, confirmed c-FlipL expression in undifferentiated spermatogonia. Further analyses showed Fas expression but no significant caspase 8/10 activity when c-FlipL was highly expressed. Altogether these data suggest that c-Flip may control the survival rate of undifferentiated spermatogonia. [Copyright &y& Elsevier]
- Subjects :
- *GERM cells
*APOPTOSIS
*STEM cells
*SPERMATOGENESIS
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 580
- Issue :
- 26
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 22965242
- Full Text :
- https://doi.org/10.1016/j.febslet.2006.10.010