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Conditions for extreme sensitivity of protein diffusion in membranes to cell environments.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 10/10/2006, Vol. 103 Issue 41, p15002-15007. 6p. 1 Diagram, 1 Graph. - Publication Year :
- 2006
-
Abstract
- We study protein diffusion in multicomponent lipid membranes close to a rigid substrate separated by a layer of viscous fluid. The large-distance, long-time asymptotics for Brownian motion are calculated by using a nonlinear stochastic Navier-Stokes equation including the effect of friction with the substrate. The advective nonlinearity, neglected in previous treatments, gives only a small correction to the renormalized viscosity and diffusion coefficient at room temperature. We find, however, that in realistic multicomponent lipid mixtures, close to a critical point for phase separation, protein diffusion acquires a strong power-law dependence on temperature and the distance to the substrate H, making it much more sensitive to cell environment, unlike the logarithmic dependence on H and very small thermal correction away from the critical point. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIFFUSION
*BILAYER lipid membranes
*BIOLOGICAL membranes
*PROTEINS
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 103
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 22876473
- Full Text :
- https://doi.org/10.1073/pnas.0606992103