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Solid-Phase Selenium-Catalyzed Selective Allylic Chlorination of Polyprenoids: Facile Syntheses of Biologically Active Terpenoids.
- Source :
-
Journal of Organic Chemistry . 7/21/2006, Vol. 71 Issue 15, p5811-5814. 5p. 1 Chart. - Publication Year :
- 2006
-
Abstract
- Regioselective halogenation of the terminal isopropylidene unit of different acyclic polyolefinic polyprenoids (farnesyl acetate, geranylgeranyl acetate, squalene, etc.) using NCS/catalytic polymer-supported selenenyl bromide is described; good to excellent yields are obtained (68–96%). The first applications of this protocol include the concise synthesis of bioactive terpenoids 1–3. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 71
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22725512
- Full Text :
- https://doi.org/10.1021/jo060760d