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A Single Nucleotide Polymorphism Fine Mapping Study of Chromosome 1q42.1 Reveals the Vulnerability Genes for Schizophrenia, GNPAT and DISC1: Association with Impairment of Sustained Attention
- Source :
-
Biological Psychiatry . Sep2006, Vol. 60 Issue 6, p554-562. 9p. - Publication Year :
- 2006
-
Abstract
- Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was >10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = −2.07, p = .038, df = 1) and haplotype association analyses (z = −1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus (z =−3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISC1 is associated with sustained attention deficits. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEOTIDES
*GENETIC polymorphisms
*SCHIZOPHRENIA
*GENE mapping
*DATABASES
Subjects
Details
- Language :
- English
- ISSN :
- 00063223
- Volume :
- 60
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 22578725
- Full Text :
- https://doi.org/10.1016/j.biopsych.2006.04.024