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Synthesis and antitumor activity of novel 10-substituted camptothecin analogues
- Source :
-
Bioorganic & Medicinal Chemistry . Nov2006, Vol. 14 Issue 21, p7175-7182. 8p. - Publication Year :
- 2006
-
Abstract
- Abstract: In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I of these derivatives were evaluated. Most of these derivatives possessed lower cytotoxicities than CPT, and the compounds 13, 21, 22, 23, and 24 showed similar topoisomerase I inhibitory activity to CPT. Analogues 13 exhibited the best antitumor activity in vivo among all derivatives we prepared. [Copyright &y& Elsevier]
- Subjects :
- *ANTINEOPLASTIC agents
*ANTIVIRAL agents
*ALKALOIDS
*CELL culture
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 14
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22472509
- Full Text :
- https://doi.org/10.1016/j.bmc.2006.06.061