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Leflunomide increases the risk of early healing complications in patients with rheumatoid arthritis undergoing elective orthopedic surgery.
- Source :
-
Rheumatology International . Oct2006, Vol. 26 Issue 12, p1138-1142. 5p. - Publication Year :
- 2006
-
Abstract
- The aim of this object is to study whether treatment with biological or leflunomide increases the risk of wound-healing complications after elective orthopedic surgery. Between March 2002 and September 2003, 201 patients participated in this study with the following inclusion criteria: (a) Rheumatoid arthritis (RA) or psoriatic arthritis (psA), (b) therapy with: MTX, leflunomide, etanercept, infliximab, adalimumab, anakinra, (c) undergoing elective orthopedic surgery. The incidence of early postoperative wound-healing complications was compared among the different groups. In comparison with patients who received MTX therapy ( n = 59), the risk of postoperative wound-healing complications in patients undergoing leflunomide therapy ( n = 32) was significantly higher: 13.6% in the MTX group, 40.6% in the leflunomide group ( P = 0.01). It is recommended that leflunomide medication for patients with RA undergoing elective orthopedic surgical procedure is interrupted preoperatively to reduce the risk of early wound-healing complications or infections. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01728172
- Volume :
- 26
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Rheumatology International
- Publication Type :
- Academic Journal
- Accession number :
- 22458569
- Full Text :
- https://doi.org/10.1007/s00296-006-0138-z